3rd Charité Zeuthener See workshop     Program   Friday 04/20/2007 14.00 - Arrival Coffee, tea, cakes 18.00 - Dinner and get-together Saturday 04/21/2007 9.00 - Opening and instructions: Peter Kloetzel Session I - Defects, presentation and quality control                      Chairs: Fred Goldberg/ Hans-Jörg Schild 9.15 - Jon Yewdell Not all Peptides are Created Equal 9.50 - Nir Netzer tRNA Misacylation as a Potential Contributor to DRiPs 10.25 - Hidde Ploegh Pathogens, the ubiquitin-proteasome pathway and protein quality control 11.00 - Coffee break 11.30 - Margarita del Val Diversity of antigen processing routes for CTL epitopes in virus-infected cells 12.05 - Christopher Tsu Quantitation of immunoproteasome activity in cells and tissues using selective substrates 12.40 - Lunch Session II - Interferons, antigen processing and functions                       Chairs: Jon Yewdell / Kenneth Rock 14.40 - Peter Kloetzel The effect of INF-ϒ on antigen processing and the ubiquitin-proteasome system 15.15 - Weisan Chen Immunoproteasome subunit deficiencies impact differentially upon two immunodominant influenza virus specific CD8+ T cell responses 15.50 - Alice Sijts Mechanisms leading to immunodominance of Listeria-derived CD8 T cell epitopes 16.25 - Scott Pruitt (10+5) Immunoproteasome Down-Modulation Enhances the Ability of Dentritic Cells to Stimulate Anti-Tumor Immunity 17.30 - Discovering the lakes around Berlin: Boat trip and dinner Sunday 04/22/2007 Session III - Mechanisms involved in antigen presentataion                        Chairs: Jack Bennink 9.00 - Hans Jörg Schild Non-proteasomal cleavage activites in the generation of MHC class I ligands 9.35 - Benoit van den Eynde Splicing of antigenic peptides by the proteasome 10.10 - Paul Lehner Ubiquitination And Disposal Of Critical Immunoreceptors By Viral Ubiquitin E3 Ligases 10.45 - Coffee Break 10.45 - 12.45     POSTER SESSION 13.00 - Lunch Session IV - Epitope trimming I                         Chairs: Hidde Ploegh/ Jacques Neefjes 14.30 - Alfred Goldberg New insights into the proteasomal function and processing of antigenic peptides by ERAP1 15.05 - Nilabh Shastri The absence of ERAAP causes MHC class I molecules to present an unedited volume of highly immunogenic peptides 15.40 Kenneth Rock Post-proteasomal antigen processing steps 16.15 Coffee Break Session V - Epitope trimming II                        Chairs: Hidde Ploegh/ Jacques Neefjes 16.40 - Peter van Endert Characterisation of an aminopeptidase with an exclusive role in cross- presentation of phagocytosed antigens 17.15 - Gabriele Niedermann Immune system alterations in ERAP1 and in TPPII knock-out mice 17.50 - Frank Momburg A complex sequence motif of tapasin stabilizes the TAP2 protein 18.25 - Ulrike Seifert (10+5) Critical role of ERAPI/II in epitope generation and destruction 19.00 - Dinner Monday 04/23/2007 Session VI - Crossing and priming                         Chairs: Margarita del Val / Peter van Endert 8.45 - Shigeo Murata "Thymoproteasomes" regulate development of CD8+ T cell in the thymus 9.20 - Jacques Neefjes Antigen (cross)-presentation following alternative protease activities as the result of apoptosis 9.55 - Ferry Ossendorp Cross-presentation and – priming by TLR ligand-conjugated antigen 10.30 - Coffee break 10.50 - Frédéric Lévy Impact of tumor antigen processing on T cell priming and response 11.25 - Marcus Groettrup (15+5) A prostate carcinoma antigen reveals a new cytosolic class I processing pathway for endoplasmic reticulum targeted proteins 11.45 - Lunch available on demand END               HOME     CONTACT     REGISTRATION     ABSTRACTS     PROGRAM     VENUE Deadline for registration: March 30th, 2007: Space is limited!