2009

Generation of in silico predicted coxsackievirus B3-derived MHC class I epitopes by proteasomes. Amino Acids. 2009 Dec 9. [Epub ahead of print]

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Int J Biochem Cell Biol. 2009 May;41(5):1205-15. Epub 2008 Nov 5.

The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities. Eur J Pharm Biopharm. 2009 May;72(1):219-25. Epub 2008 Nov 7.

Alveolar extracellular 20S proteasome in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2009 Jun 15;179(12):1098-106. Epub 2009 Mar 12.

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome. NSMB, 2009 Feb;16(2):219-25. Epub 2009 Jan 25.

Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis. 2009 Aug;175(2):510-8.
Epub 2009 Jul 9

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Int J Biochem Cell Biol. 2008 Nov 5.
[Epub ahead of print]



  2008

Ubxd1 is a novel co-factor of the human p97 ATPase.Inter. J Biochem Cell Biol 40, 2927-2942 (2008)

Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo.J Cell Sci 121, 458-465 (2008)

Derlin.1 and p97/Valosin - containing protein mediate the endoplasmic reticulum-associated degration of human V2 vasopressin receptors. Mol Pharmacol 73, 697-708 (2008)

Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (ß1i), MECL1 (?2i) and LMP7 (ß5i). Rheumatology 47, 622-626 (2008)

Pioglitazone, a PPAR-? ligand, exerts cytostatic/cytotoxic effects against cancer cells, that do not result from inhibitition of proteasome. Acta Biochim Pol 55, 75-84(2008)

The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities. 2008 Nov 7. [Epub ahead of print]

Blm10 binds to pre-activated proteasome core particles with open gate conformation. EMBO Reports 2008. (in press)

Remodelling of the ubiquitin-proteasome system in response to interferons. Biochem Soc Trans. 2008 Oct; 36(Pt5):879-84

Mammalian 26S proteasomes remain intact during protein degradation. Cell. 2008 Oct 17, 135:1-10

Synthesis of full length PB1-F2 influenza A virus proteins from 'Spanish flu' and 'bird flu'. J Pept Sci. 2008 Aug;14(8):954-62.

Phage display screening for peptidic chitinase inhibitors. J Mol Recognit. 2008 Aug 5.

Extracellular, circulating proteasomes and ubituitin – Incidence and relevance. Biochem. Biophys. Acta 2008 Jun 18

Antitopes define preferential proteasomal cleavage site usage. 2008 Jun 27;283(26):17891-7. Epub 2008 Apr 18

Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics. J Mol Biol. 2008 Apr 11;377(5):1607-17. Epub 2008 Feb 8.

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma. Eur J Haematol. 2008 Feb;80(2):133-42. Epub 2007 Dec 20.



  2007

Role of proteasomes in disease. BMC Biochem. 2007 Nov 22; 8 Suppl 1:S3. Review

Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver. J Interferon Cytokine Res. 2007 27(12):985-90

Antibody to Ap1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol. Biol. Cell 18, 4872-4884 (2007)

The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO Rep. 2007 ;8:1170-5

Synergistic interaction of the histone deacetalase inhibitor SAHA with the proteasome. Eur J Haematol. 2007 Nov 15 [Epub ahead of print]

Intermediate-type 20S proteasomes in HeLa cells: ´´Asymmetric`` Subunit composition, diversity and adaptation. J.Mol.Biol. 373, 1-10 (2007)

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13690-5.

Using intrinsic X-ray absorption spectral differences to identify and map peptides and proteins. J Phys Chem B. 2007 Jul 5;111(26):7691-9.

Proline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the integrity of the N-terminal helix and the incorporation of Vpr into virus particles and supports the replication of R5-tropic HIV-1 in human lymphoid tissue ex vivo. J Virol. 2007 Sep;81(17):9572-6.

The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. J Mol Med. 2007 Sep;85(9):961-70.

The N-terminal flanking region of the TRP2360-368 melanoma antigen determines proteasome activator PA28 requirement for epitope liberation. J Biol Chem. 2007 Apr 27;282(17):12749-54.

Heme Oxygenase-1 Ameliorates Ischemia/Reperfusion Injury by Targeting Dendritic Cell Maturation and Migration. Antioxid Redox Signal. 2007 Sep 13; [Epub ahead of print]

Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma. Blood. 2007 Mar 1;109(5):2100-5. Epub 2006 Nov 9.

Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice. Am J Physiol Endocrinol Metab. 2007 Mar 27; [Epub ahead of print]

Thrombin-mediated hepatocellular carcinoma cell migration: Cooperative action via proteinase-activated receptors 1 and 4.J Cell Physiol. 2007 Jun;211(3):699-707.

Structure, dynamics and topology of membrane polypeptides by oriented (2)H solid-state NMR spectroscopy. Eur Biophys J. 2007 Apr;36(4-5):451-60

20S proteasome-dependent generation of an IEpp89 murine cytomegalovirus-derived H-2L(d) epitope from a recombinant protein. Biochem Biophys Res Commun. 2007 Apr 6;355(2):549-54. Epub 2007 Feb 8.

Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein.J Biol Chem. 2007 Jan 5;282(1):353-63..

Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E40-8.

The 20S proteasome isolated from Alzheimer's disease brain shows post-translational modifications but unchanged proteolytic activity. J Neurochem. 2007 ;101:1483-90.

Role of proteasomes in disease. BMC Biochem. 2007 Nov 22;8 Suppl 1:S3. Review



  2006

Anti-proteasome autoantibodies contribute to anti-nuclear antibody patterns on human larynx carcinoma cells. Ann Rheum Dis. 2007 Jan;66(1):5-11. Epub 2006 Jun 30.

Rhodopsin-transducin coupling: role of the Galpha C-terminus in nucleotide exchange catalysis. Vision Res. 2006 Dec;46(27):4582-93.

Sequence requirements and an optimization strategy for short antimicrobial peptides. Chem Biol. 2006 Oct;13(10):1101-7.

Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8+ T cells. J Immunol. 177, 6238-44 (2006).

Comprehensive quantitative proteome analysis of 20S proteasome subtypes from rat liver by liquid chromatography and 2-DE based approaches. Proteomics 6, 4622-4632 (2006)

Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection. J Clin Invest. 2006 Nov;116(11):3006-14. Epub 2006 Oct 12.

Effects of transgenic expression of HIV-1 viral protein R (Vpr) on lipid and energy metabolism in mice. Am J Physiol Endocrinol Metab (2006).

PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration. Oncol Rep 15, 889-93 (2006).

Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28. Arthritis Rheum 54, 2175-83 (2006).

Anti-Proteasome autoantibodies contribute to ANA- patterns on HEp-2 cells. Ann Rheum Dis (2006).

Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency. Cancer Res 66, 649-52 (2006).

Signal transfer from GPCRs to G proteins: Role of the Galpha N-terminal region in rhodopsin - transducin coupling. J Biol Chem (2006).

Identification of HIV-1 Tat peptides for future therapeutic angiogenesis. Eur J Haematol 77, 157-65 (2006).

The effects of the histone deacetylase inhibitor valproic acid on cell cycle, growth suppression and apoptosis in multiple myeloma. Haematologica 91, 248-51 (2006).

Immunoproteasome subunit LMP2 expression is deregulated in Sjogren's syndrome but not in other autoimmune disorders. Ann Rheum Dis 65, 1021-7 (2006).

A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms. Biol Chem 387, 417-29 (2006).

Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells. Cancer Res 66, 7598-605 (2006).

Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomes. Am J Pathol 168, 1542-52 (2006).

  2005

HLA-B27-restricted CD8+ T cell response to cartilage-derived self peptides in ankylosing spondylitis. Arthritis Rheum 52, 892-901 (2005).

Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines. J Biol Chem 280, 28394-401 (2005).

Proteasomes. Essays Biochem 41, 31-48 (2005).

Solution structure of the human immunodeficiency virus type 1 p6 protein. J Biol Chem 280, 42515-27 (2005).

Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications. Chem Commun (Camb), 1830-2 (2005).

IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. Proc Natl Acad Sci U S A 102, 9241-6 (2005).

Influenza A virus protein PB1-F2: synthesis and characterization of the biologically active full length protein and related peptides. J Pept Sci 11, 481-90 (2005).

The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. Curr Biol 15, 1217-21 (2005).

Consequences of COP9 signalosome and 26S proteasome interaction. Febs J 272, 3909-17 (2005).

Proteinase-activated receptors (PARs)--the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1. Regul Pept 125, 61-6 (2005).

Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells. J Immunol 174, 7815-22 (2005).

SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol 3, e41 (2005).

The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. J Mol Biol 354, 1021-7 (2005).

Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing. Immunol Rev 207, 19-30 (2005).

Modeling the MHC class I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class I binding. Cell Mol Life Sci 62, 1025-37 (2005).

Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation. J Virol 79, 4479-91 (2005).

  2004

Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J Immunol 173, 5794-800 (2004).

PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes. J Virol 78, 6304-12 (2004).

PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. Oncol Res 14, 475-82 (2004).

Sequence of interactions in receptor-G protein coupling. J Biol Chem 279, 24283-90 (2004).

The proteasome and MHC class I antigen processing. Biochim Biophys Acta 1695, 225-33 (2004).

Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII. Nat Immunol 5, 661-9 (2004).

Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol 16, 76-81 (2004).

Prevalence of 20S proteasome, anti-nuclear and thyroid antibodies in young patients at onset of type 1 diabetes mellitus and the risk of autoimmune thyroiditis. J Pediatr Endocrinol Metab 17, 975-81 (2004).

Untersuchungen zum Nachweis von TSE mittels Antikörpern. Fleischwirtschaft 7, 97-99 (2004).

Rearrangement of the 16S precursor subunits is essential for the formation of the active 20S proteasome. Biophys J 87, 4098-105 (2004).

Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp 259, 182-93; discussion 193-6, 223-5 (2004).

3-aminobicyclo[1.1.1]pentane-1-carboxylic acid derivatives: synthesis and incorporation into peptides. Eur. J. Org. Chem. 2204, 493-498 (2004).

Hepatitis C virus mutation affects proteasomal epitope processing. J Clin Invest 114, 250-9 (2004).

Sorting competition with membrane-permeable peptides in intact epithelial cells revealed discrimination of transmembrane proteins not only at the trans-Golgi network but also at pre-Golgi stages. J Biol Chem 279, 17376-83 (2004).

Organ-specific pathology of the small intestine mediated by hsp60 CD8+ T cells: proteasomal antigen processing is different in the small intestine and colon. In: Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD. (Eds.: Duchmann, R. et al.) Kluwer Academic Publishers Dordrecht/Boston/London, pp. 53-62 (2004).

Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast. J Mol Biol 344, 697-706 (2004).

The bipartite nuclear localization sequence of Rpn2 is required for nuclear import of proteasomal base complexes via karyopherin alphabeta and proteasome functions. J Biol Chem 279, 37751-62 (2004).



  2003

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. FEBS Lett 553, 200-4 (2003).

Structural characterization of the HIV-1 Vpr N terminus: evidence of cis/trans-proline isomerism. J Biol Chem 278, 43188-201 (2003).

Complex polyfluoride additives in Fmoc-amino acid fluoride coupling processes. Enhanced reactivity and avoidance of stereomutation. Org Lett 5, 975-7 (2003).

Wer kontrolliert das 26S Proteasom, ein Schlüsselenzym regulierter Proteolyse? Bioforum 7-8, 448-9 (2003).

Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly. EMBO Rep 4, 959-63 (2003).

A comprehensive view on proteasomal sequences: implications for the evolution of the proteasome. J Mol Biol 326, 1437-48 (2003).

MAPPP: MHC class I antigenic peptide processing prediction. Appl Bioinformatics 2, 155-8 (2003).

Transferring substrates to the 26S proteasome. Trends Biochem Sci 28, 26-31 (2003).

Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell 12, 167-76 (2003).

Production, purification, and characterization of rat pro-CCK from serum-free adapted Drosophila cells. Protein Expr Purif 31, 56-63 (2003).

The components of the proteasome system and their role in MHC class I antigen processing. Rev Physiol Biochem Pharmacol 148, 81-104 (2003).

Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes. J Biol Chem 278, 21517-25 (2003).

Alteration of 20S proteasome-subtypes and proteasome activator PA28 in skeletal muscle of rat after induction of diabetes mellitus. Int J Biochem Cell Biol 35, 740-8 (2003).

Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodies. Arthritis Rheum 48, 475-85 (2003).

Immunisation with a synthetic prion protein-derived peptide prolongs survival times of mice orally exposed to the scrapie agent. Neurosci Lett 350, 187-9 (2003).

Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins. J Biol Chem 278, 16791-6 (2003).

An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat Immunol 4, 375-9 (2003).

Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit. Biol Chem 384, 39-49 (2003).

Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. Embo J 22, 1302-12 (2003).

Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression. J Biol Chem 278, 43202-13 (2003).



  2002

The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis. J Cell Sci 115, 467-73 (2002).

Ubiquitin system: JAMMing in the name of the lid. Curr Biol 12, R815-7 (2002).

The glycoprotein gp48 of murine cytomegalovirusL proteasome-dependent cytosolic dislocation and degradation. J Biol Chem 277, 2216-24 (2002).

The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts. Angew Chem Int Ed Engl 41, 441-5 (2002).

Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. Embo J 21, 2715-23 (2002).

Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases. J Rheumatol 29, 2045-52 (2002).

The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. J Mol Biol 323, 771-82 (2002).

PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells. Int J Oncol 20, 177-80 (2002).

Benefits and hazards of protein destruction (book review). Nature Cell Biol. 4 (2002).

The effect of the interferon-gamma-inducible processing machinery on the generation of a naturally tumor-associated human cytotoxic T lymphocyte epitope within a wild-type and mutant p53 sequence context. Eur J Immunol 32, 1368-75 (2002).

Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity. J Exp Med 195, 983-90 (2002).

20 S proteasomes are imported as precursor complexes into the nucleus of yeast. J Mol Biol 317, 401-13 (2002).

Ubiquitin-proteasome pathway as a new target for the prevention of restenosis. Circulation 105, 483-9 (2002).

Assessment of proteasomal cleavage probabilities from kinetic analysis of time-dependent product formation. J Mol Biol 318, 847-62 (2002).

HIV-1 Vpr displays natural protein-transducing properties: implications for viral pathogenesis. Virology 302, 95-105 (2002).

The role of the proteasome activator PA28 in MHC class I antigen processing. Mol Immunol 39, 165-9 (2002).

Inhibition of the ubiquitin-proteasome pathway induces differential heat-shock protein response in cardiomyocytes and renders early cardiac protection. Biochem Biophys Res Commun 291, 542-9 (2002).

Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells. Cancer Res 62, 2875-82 (2002).

PI31 is a modulator of proteasome formation and antigen processing. Proc Natl Acad Sci U S A 99, 14344-9 (2002).



  2001

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. Embo J 20, 1630-9 (2001).

The solid state and solution structure of HAPyU. J Org Chem 66, 5245-7 (2001).

A novel influenza A virus mitochondrial protein that induces cell death. Nat Med 7, 1306-12 (2001).

Subtypes of 20S proteasomes from skeletal muscle. Biochimie 83, 295-9 (2001).

The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase. FEBS Lett 505, 325-31 (2001).

Antigen processing by the proteasome. Nat Rev Mol Cell Biol 2, 179-87 (2001).

The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide. J Immunol 167, 1515-21 (2001).

Reconstitution of hybrid proteasomes from purified PA700-20 S complexes and PA28alphabeta activator: ultrastructure and peptidase activities. J Mol Biol 313, 465-71 (2001).

20S proteasome biogenesis. Biochimie 83, 289-93 (2001).

Clp-mediated proteolysis in Gram-positive bacteria is autoregulated by the stability of a repressor. Embo J 20, 852-63 (2001).

Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases. J Immunol 167, 4738-46 (2001).

Synthesis, characterization, and biological properties of cyanine-labeled somatostatin analogues as receptor-targeted fluorescent probes. Bioconjug Chem 12, 44-50 (2001).

The role of the ubiquitin-proteasome pathway in MHC class I antigen processing: implications for vaccine design. Curr Mol Med 1, 665-76 (2001).

Defined flanking spacers and enhanced proteolysis is essential for eradication of established tumors by an epitope string DNA vaccine. J Immunol 166, 5366-73 (2001).

A novel PAR-1-type thrombin receptor signaling pathway: cyclic AMP-independent activation of PKA in SNB-19 glioblastoma cells. Biochem Biophys Res Commun 282, 952-7 (2001).